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Distribution of cases by Stage and Histology 4Table 2. Women with recorded FIGO Stage by age group &There are no cases under the age of 2035-6465+STABLE 3 Percentage of women with NO adequate smears up to 6 months before diagnosisETABLE 4A Breakdown of screening histories in women aged between 20-65QNote: As we receive more data smaller age groups will be used to present the data>Note: many of the reviews were carried out by one person only. InadequateOtherrNote: consensus review result is the most severe result reported upon review (combining local and regional review)AdenosqNorth West QARCOriginal ResultOriginal Result Unknown Other/UndiffKThe maximal screening interval is the longest period during the 8 years prior to diagnosis in which the woman did not have a smear test. For this analysis inclusion criteria was restricted to women aged 30-69 to allow sufficient time during which a woman was eligible for screening so as to be able to determine her usual interval.TABLE 3a. Percentage of women with cancer not known to be stage 1A (i.e. stage 1B+ and missing stage) who have no adequate smears up to 6 months before diagnosis "#pTABLE 5 Cases with a screening history indicative of referral to colposcopy at least 6 months prior to diagnosis3Screening history indicating referral to colposcopy8Recorded colposcopy at least 4 months prior to diagnosisNonePunchTreated at colp Not treatedUnclear$Diagnosis 6-18 months after referral'Diagnosis over 18 months after referral>History of referral followed by two negatives before diagnosis\ None means that there is a colposcopy recorded for this woman within 4 months of diagnosisJThe following tables show original and review results by histological typeNThe following tables show original and review results by time before diagnosis^Table 4a. Original versus review results in smears taken less than six months before diagnosis_Table 4c. Original versus review results in smears taken between 3.5-5.5 years before diagnosis]Table 4d. Original versus review results in smears taken more than 5.5 years before diagnosis2(2%)3(1%)H Controls in this table for women with cancer stage 1B+ and missing onlyG2 women are missing original diagnosis or review result (details below)(Note: the following IDs are missing data)SOP/QC7/2007/0361 - no original diagnosis#CU/QDK/2007/0011 - no review result9Table 1. Original biopsy diagnosis by worst review result Review ResultnNote: worst review result is the most severe result reported upon review (combining local and regional review)Histology reviewTable 1a. Pooled original smear results versus worst* review result. Including all QARCs that provided data up to November 2008  NX HTable 3a. Squamous carcinoma cases original versus worst review results DTable 3b. Adenocarcinoma cases original versus worst review results GTable 3c. Adeno-squamous carcinoma original versus worst review resultsHTable 3e. Unknown histology cancers original versus worst review resultsgTable 1. Comparison of original smear results with the consensus review results for the North West QARC X Total (100%)*Note: worsts review result is the most severe result reported upon review (except where a consensus was specified in which case it is the consensus result) hTable 4b. Original versus review results in smears taken between 6 months and 3.5 years before diagnosisOriginal DiagnosiskNote: three case have no GP control. Two district controls have no recorded date of birth and were dropped.2Of these 396 cases were between the ages of 20-65 )Microinvasive means FIGO stage 1A (n=129)*1B+ means FIGO stage 1B or greater (n=274)Y*as of June 2009, it includes cases diagnosed from the 29 January 2007 to the 19 May 2009108(84%)17(13%)3(2%) 129(100%)196(72%)62(23%)9(3%)4(1%) 274(100%)22(21%)4(4%)1(1%)101(20%)14(3%)7(1%)6(1%)59(46%)48(37%)16(12%)5(4%)32(23%)50(36%)33(24%)15(11%)9(6%) 139(100%)3(8%)10(27%)9(24%)11(30%)4(11%)37(100%)2(6%)3(9%)11(34%)10(31%)6(19%)32(100%)96(28%)111(33%)69(20%)41(12%)20(6%) 337(100%)N*Note: Cases registered as IN (invasive) are not included in this table (N=66)&Note: there are 7 cases under age 25. Three were diagnosed on her first ever smear (prevalent), two were screen-detected following a previous negative smear 3 years earlier, one woman was diagnosed 2.3 years after a negative smear and one women was diagnosed after a history of abnormal smears. 28%(5/18)9%(5/54) 22%(49/227) 4%(25/564) 40%(17/42) 21%(34/159) 17%(10/59)8%(5/64)17%(1/6) 12%(16/129) 30%(7/23) 14%(12/84) 34%(92/270)74(9%)15(12%)51(25%)10(14%)269(34%)20(10%)123(16%)30(24%)26(13%)117(15%)28(23%)50(25%)21(29%)61(8%)8(7%)11(5%)22(3%)13(11%)14(7%)104(13%)10(8%)12(6%)2(3%)21(3%)17(14%)17(8%)11(15%) 791(100%) 123(100%) 201(100%)72(100%)2A total of 603 smears from 212 cases were reviewedBenignCIN1 Non-cervical887 cases do not have a cytology recorded in the database0208 cases have a cytology recorded but no reviewdA total of 406 biopsies from 311 cases were reviewed. There are 196 cases without a recorded biopsyn=1819n=266n=295n=109n=120n=601n=192n=197n=3599TThere are a total of 506 cases and 1007 controls (matched on age and GP or District)*20% of all cases are missing stage (n=103)74(72%)378(75%) 506(100%) 103(100%) 44%(33/73) 30%(84/274) 35%(76/216) 15%(150/1007) 27%(28/103) 58%(18/31) 16%(123/749)66-79; _;j;<<G<V=a]>h>>G@RAD vE G IL&NN4O?OOP'QGRRRR 00_)\([$#,##}(}? 00_)}(}o 00_)}t}p`?BC?}(}s }(}w 4}t}|`?BC?}(}~ 4}<} }(} }(} }(} }(} }t}`?BC?}(} }(} }(} }t}`?BC?}(} }(} }(} }(} }(} }(} }(} }t}`?BC?}(} }(} H 20% - Accent1 ef H" 20% - Accent2 ef H& 20% - Accent3 ef H* 20% - Accent4 ef H. 20% - Accent5 ef H2 20% - Accent6  ef H 40% - Accent1 L H# 40% - Accent2 L湸 H' 40% - Accent3 L H+ 40% - Accent4 L H/ 40% - Accent5 L H3 40% - Accent6  Lմ H 60% - Accent1 23 H$ 60% - Accent2 23ٗ H( 60% - Accent3 23֚ H, 60% - Accent4 23 H0 60% - Accent5 23 H4 60% - Accent6  23 <Accent1 O <!Accent2 PM <%Accent3 Y <)Accent4 d <-Accent5 K <1Accent6  F 4Bad  | Calculation  } z Check Cell  ????????? ??? 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